TY  - JOUR
AU  - WU, Chenghao
AU  - WEI, Dali
AU  - DENG, Chunmeng
AU  - WANG, Peixia
AU  - PAN, Teng
AU  - ZHANG, Zhen
PY  - 2026
TI  - Research Progress on Analytical Methods for Dextromethorphan and Its Metabolites
JO  - Chinese Journal of Forensic Sciences
SN  - 1671-2072
SP  - 21
EP  - 31
VL  - 2026
IS  - 1
AB  - The illegal abuse of dextromethorphan, a widely used antitussive drug in clinical practice, has increasingly become an international issue. Currently, China has listed dextromethorphan in its national catalog of Category II Psychotropic Drugs and implements control measures in accordance with standards for narcotics regulation. Based on relevant literature, this study summarizes the metabolic pathways, abuse hazards, and control status of dextromethorphan, with a focus on the extraction and detection methods for dextromethorphan and its metabolites. It analyzes and discusses the applicability of these methods across different matrices, their qualitative and quantitative detection performance, and their multidimensional application scenarios in forensic appraisal. This study aims to provide a reference for the detection, identification, and abuse monitoring of dextromethorphan in the field of forensic appraisal.
UR  - https://doi.org/10.3969/j.issn.1671-2072.2026.01.003
DO  - 10.3969/j.issn.1671-2072.2026.01.003