@article{Tan2025, 
author = {Min-Hui Tan and Ou-Hai Liang and Xin Lin and Yanhao Huang},
title = {Apelin-13 improves post-ischemic cognition by restoring APLN and microglia rhythmicity in aging},
year = {2025},
journal = {Aging Research},
volume = {3},
number = {4},
pages = {9340075},
keywords = {aging, Apelin, Apelin-13, cerebral ischemia-reperfusion injury},
url = {https://www.sciopen.com/article/10.26599/AGR.2025.9340075},
doi = {10.26599/AGR.2025.9340075},
abstract = {Aging increases susceptibility to cerebral ischemia and weakens endogenous protective pathways. We found that Apelin/APLN expression, especially the bioactive Apelin−13 isoform, is markedly reduced in aged mouse brains, and the normal ischemia−induced upregulation of Apelin is blunted. Glial rhythmicity analysis further showed that Apelin expression exhibits clear oscillations in young astrocytes and microglia but becomes disrupted with aging. Apelin−13 supplementation significantly improved post−ischemic learning and memory in aged mice, increased endogenous Apelin-13 levels, reduced TNF−α and IL−6, and enhanced IL−10 expression.These findings indicate that aging disrupts Apelin−dependent neuroprotective and rhythmic pathways, and that Apelin−13 effectively restores inflammatory balance and cognitive recovery after cerebral ischemia, highlighting its potential as a therapeutic strategy for aging−related stroke vulnerability.}
}