@article{YANG2025, 
author = {Ye YANG and Haibo ZHANG and Yanji LIU and Zhongxiang YAO and Bo HU},
title = {Effects of clesmatine on myelination and neuronal activity during sleep in the hippocampus of adult APP/PS1 mice},
year = {2025},
journal = {Journal of Army Medical University},
volume = {47},
number = {16},
pages = {1838-1848},
keywords = {myelin, hippocampus, sleep, neural oscillation, multiple-channels recording},
url = {https://www.sciopen.com/article/10.16016/j.2097-0927.202505023},
doi = {10.16016/j.2097-0927.202505023},
abstract = {ObjectiveTo investigate the effects of clesmatine on the myelination and neural oscillation-related firing activities during sleep in the hippocampus of adult APP/PS1 mice.MethodsOral administration of clemastine in drinking water was given to APP/PS1 mice for 3 months to enhance myelination in adulthood. Based on the treatment regimens, the mice were randomly assigned into APP/PS1 group, APP/PS1+clemastine group, and wild-type (WT) group. Local field potentials combined with three-dimensional acceleration of the head and neck were employed to determine the brain states, that is, wakefulness, non-rapid eye movement (NREM) sleep, REM sleep. In vivo multi-electrode arrays were utilized to continuously monitor neuronal firing activities in the dorsal hippocampus across the 3 sleep states.Results① Oral clemastine administration via drinking water significantly increased MBP+ protein expression levels in APP/PS1+Clemastine mice than the APP/PS1 controls (P < 0.001). ② Clemastine administration did not alter the time proportions of NREM sleep, REM sleep and wakefulness during the daytime phase in APP/PS1 mice (Ps > 0.05). ③ Clemastine administration obviously reduced the mean firing rate of hippocampal pyramidal cells (P < 0.05) while increasing that of hippocampal interneurons (P < 0.05) in APP/PS1 mice. ④ Clemastine administration increased the occurrence rate of hippocampal sharp wave-ripple (SWR) oscillations during NREM sleep and specifically reduced the firing rate of pyramidal cells during SWR oscillations in APP/PS1 mice (P < 0.05). ⑤ Clemastine administration had no significant effect on the P hippocampal neuronal firing activity during theta oscillation in REM sleep in APP/PS1 mice (Ps > 0.05).ConclusionClemastine administration not only enhances the adult myelination, but also rescues both the SWRs and associated hippocampal neuronal firing during NREM sleep in APP/PS1 mice.}
}