@article{Wang2026, 
author = {Xiaozhen Wang and Wenya Su and Xia Li and Han Xu and Hongyue Tian and Luqi Huang and Lanping Guo and Wenyuan Gao},
title = {Prebiotic-based "Shield" hydrogel embedded with rod-shaped Mn2(Olsa) MOF particles for inflammatory bowel disease and associated mental disorders},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {9},
pages = {94908754},
keywords = {hydrogel, inflammatory bowel disease, colon-targeted delivery, anxiety-like and depression-like behaviors},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908754},
doi = {10.26599/NR.2026.94908754},
abstract = {Inflammatory bowel disease (IBD), with its colonic predilection, was frequently complicated by neuropsychiatric comorbidities such as anxiety and depression. To address this, we developed a colon-targeted, prebiotic-based synergistic therapeutic system. This system integrated anti-inflammatory and antioxidative rod-shaped Mn2(Olsa) metal-organic framework (MOF) particles with a yeast β-glucan/konjac glucomannan (YG/KGM) composite gel designed to remodel the gut microenvironment. The resulting Mn2(Olsa)/Gel composite ensured sustained intestinal adhesion and retention, facilitating efficient colon-targeted delivery. It effectively alleviated hallmark pathologies of IBD, including intestinal inflammation, microbial dysbiosis, barrier disruption, oxidative stress, and immune imbalance. In addition, the treatment significantly mitigated IBD associated anxiety- and depression-like behaviors. This work establishes a novel, targeted paradigm for the combined management of IBD and its neuropsychiatric comorbidities.}
}