@article{XIA2026, 
author = {Li XIA and Sijie ZHAO and Yang HU and Yafei WAN},
title = {Effects of polysaccharide liposomes of dendrobium officinale targeting hair follicles in the treatment of androgenetic alopecia},
year = {2026},
journal = {Journal of China Pharmaceutical University},
volume = {57},
number = {2},
pages = {224-232},
keywords = {dendrobium officinale polysaccharides, androgenic alopecia, liposomes, hair follicle targeting, human dermal papilla cells},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2025091401},
doi = {10.11665/j.issn.1000-5048.2025091401},
abstract = {Based on previous research on the promoting effect of dendrobium officinale polysaccharides (DOP) on hair growth, this study aimed to regulate the skin keratin penetration and hair follicle targeting ability of DOP through molecular weight and nano-carriers to enhance its therapeutic effect on androgenetic alopecia (AGA). Three molecular weight polysaccharides, namely high (DOP), medium (MDOP), and low (LDOP), were prepared by mannanase hydrolysis, and the corresponding liposomes (DOP-lip/MDOP-lip/LDOP-lip) were constructed. Studies have shown that DOP liposomes can effectively achieve follicular targeted delivery and promote efficient uptake by human dermal papilla cells through caveolin-mediated pathways. In the testosterone-induced AGA mouse model, LDOP-lip demonstrated excellent therapeutic effects, restoring the number and morphology of hair follicles to nearly normal levels. In summary, DOP liposomes show significant potential for promoting hair follicle repair through precise delivery and efficient cellular uptake.}
}