@article{CHEN2026, 
author = {Fangsu CHEN and Junjie YANG and Jiayu DU and Shimiao HUANG and Yuxuan ZHANG and Qidong YOU and Lei WANG and Qiuyue ZHANG},
title = {New trends and new strategies of drug repurposing: 2020–2024},
year = {2026},
journal = {Journal of China Pharmaceutical University},
volume = {57},
number = {1},
pages = {11-18},
keywords = {drug repurposing, drug development strategies, new indications, research progress},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2025072102},
doi = {10.11665/j.issn.1000-5048.2025072102},
abstract = {The research and development of innovative drug have progressed remarkably, but the long development circle and high failure rate have become the bottleneck. Drug repurposing, discovering new indications of approved drugs, is a strategy to overcome these obstacles. By exploring new indications for approved drugs, rapid progress has been made in basic research and clinical translation in recent years. Rich resources of drugs, proven security, efficient development workflow and reduced cost are core advantages of this strategy, making the strategy a crucial direction of optimizing the pipeline of drug research and development. This review systematically summarizes drug repurposing cases that have received clinical approval over the past five years, and proposes core strategies for drug repurposing, including approaches based on targets, pathways, drug similarity, post-treatment phenotypes, and clinical side effects, aiming to provide some strategic guidance for drug repurposing efforts.}
}