TY  - JOUR
AU  - ZHANG, Jing
AU  - LI, Depeng
AU  - YU, Bin
AU  - LI, Zhiyu
AU  - BIAN, Jinlei
PY  - 2026
TI  - Research advances in STING agonist-based antibody-drug conjugates
JO  - Journal of China Pharmaceutical University
SN  - 1000-5048
SP  - 19
EP  - 27
VL  - 57
IS  - 1
AB  - Immune-stimulating antibody drug conjugate (ISAC) can not only effectively solve the defects of stimulator of interferon genes (STING) agonists by coupling antibodies with STING agonists through the targeting of antibodies, but also play a synergistic role with antibodies to further improve the efficacy of STING agonists. This review first provides a concise overview of the current research landscape of ISACs and STING agonists, systematically elaborates on evolving trends in STING agonist development, and subsequently summarizes the mechanistic advances in STING ISAC research. Special emphasis is placed on representative STING ISAC candidates in preclinical/clinical development. Finally, the future directions of STING ISACs are critically discussed with perspectives and recommendations, aiming to provide theoretical insights and practical guidance for future investigations.
UR  - https://doi.org/10.11665/j.issn.1000-5048.2025031201
DO  - 10.11665/j.issn.1000-5048.2025031201