TY  - JOUR
AU  - CHEN, Yi
AU  - WEI, Jingjing
AU  - FU, Guojing
AU  - JIA, Min
AU  - CAO, Xiaoxuan
AU  - GUO, Chunyan
AU  - ZHANG, Yunfan
AU  - ZHANG, Yunling
PY  - 2025
TI  - Pathogenesis evolution law of headache diseases from the concept of "diaphragmatic phlegm and wind syncope headache"
JO  - Journal of Beijing University of Traditional Chinese Medicine
SN  - 1006-2157
SP  - 1724
EP  - 1730
VL  - 48
IS  - 12
AB  - General Treatise on Causes and Manifestations of All Diseases introduces the concept of "headache due to diaphragmatic phlegm and wind syncope" and elucidates the evolutionary pattern of headache pathogenesis: "the accumulation of diaphragmatic phlegm is the root cause, the attack of wind syncope is the manifestation, and long-term illness invading the collaterals leads to blood stasis." Building upon the traditional understanding of single-disease syndromes, this study extends this pathogenic evolution to the broader context of primary headaches, demonstrating its universal applicability across different types, including migraine, tension-type headache, and cluster headache. The accumulation of diaphragmatic phlegm is the fundamental pathological basis for headache onset. It obstructs the region between the diaphragms and disrupts the ascending-descending movement of qi, resulting in the failure of clear yang to ascend and turbid yin to descend, thus laying a pathological risk for the onset of headache. The attack of wind syncope serves as the key trigger for acute headache episodes. When wind pathogens, accompanied by phlegm, surge upward to the clear orifices, they disturb qi and blood flow and disrupt brain collaterals, triggering acute and severe headache. Chronic and persistent headaches arise from long-standing invasion of the collaterals, where phlegm and blood stasis become deeply intertwined and difficult to disperse, causing prolonged obstruction of the cerebral vessels and refractory pain. These three factors undergo dynamic evolution and mutual transformation. Based on this understanding, a staged treatment principle is proposed: regulating the diaphragm and resolving phlegm during the remission phase; calming wind and relieving syncope during the acute attack period; and dredging collaterals and tonifying deficiency during the chronic period. This approach embodies the principle of "preventive treatment of disease" and the concept of treating both the root cause and manifestations, providing new theoretical guidance for the clinical differentiation and treatment of headaches.
UR  - https://doi.org/10.3969/j.issn.1006-2157.2025.12.011
DO  - 10.3969/j.issn.1006-2157.2025.12.011