@article{FENG2026, 
author = {Yun FENG and Yan FENG and Li YU},
title = {Research progress on the role of Porphyromonas gingivalis in the progression of tumor},
year = {2026},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {34},
number = {2},
pages = {180-190},
keywords = {Porphyromonas gingivalis, periodontitis, tumor, oral squamous cell carcinoma, systemic diseases, dysbacteriosis, carcinogenic mechanisms, early diagnosis and treatment, oral health},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.202550222},
doi = {10.12016/j.issn.2096-1456.202550222},
abstract = {Periodontitis is a chronic inflammatory disease. The heterotopic colonization of periodontal pathogens results in the development of several systemic diseases. Porphyromonas gingivalis (P. gingivalis), a key pathogen for periodontitis, has been linked to the development of various cancers, such as oral squamous cell carcinoma (OSCC), lung cancer, esophageal cancer, pancreatic cancer, colorectal cancer, cervical cancer, and prostate cancer. P. gingivalis promote the progression of tumor through various mechanisms, P. gingivalis regulates proteins targeting cell cycle and apoptosis to promote proliferation of tumor cells directly, enhances tumor stemness by upregulating the expression of cluster of differentiation 44 (CD44) and cluster of differentiation 133 (CD133), activates inflammasome and p38/c-Jun N-terminal kinase 1(JNK) pathways, regulates tumor-associated neutrophil (TAN) polarization to remodel the tumor microenvironment, regulates epithelial-mesenchymal transition (EMT) to promote tumor metastasis, remodel macrophage function to evade host immune response, and regulates multi-communicating with symbiotic bacteria. In addition, P. gingivalis accelerates the progression of esophageal cancer, pancreatic cancer, colorectal cancer, and prostate cancer by promoting cell proliferation, inhibiting apoptosis, inducing chronic inflammation, and escaping immunity. However, the oral microbiome is a complex system, whether the interactions between oral bacteria affect tumor progression needs to be further investigated.}
}