@article{Baytaroğlu2026, 
author = {Ata Baytaroğlu and Suzan Doğruya and I. Merve Uçar Baytaroğlu},
title = {Evaluation of retina and choroid via OCT in anti-DFS70/LEDGF positive healthy individuals},
year = {2026},
journal = {International Journal of Ophthalmology},
volume = {19},
number = {3},
pages = {532-538},
keywords = {anti-DFS70 antibodies, choroidal vascularity index, optical coherence tomography, autoimmunity},
url = {https://www.sciopen.com/article/10.18240/ijo.2026.03.14},
doi = {10.18240/ijo.2026.03.14},
abstract = {AIMTo investigate the association between anti-DFS70 antibody positivity and ocular parameters, specifically, the choroidal vascularity index (CVI) and other optical coherence tomography (OCT) metrics, in a healthy population.METHODSThis age- and sex-matched case-control study enrolled 84 healthy individuals with positive anti-DFS70 antibody findings and 84 healthy negative controls. All participants underwent detailed ophthalmological examinations, including biometry and OCT imaging. Anti-DFS70 positivity was determined by indirect immunofluorescence and scored semi-quantitatively (1+ to 3+). CVI was calculated from OCT images using a standardized protocol with Image J software. Statistical analyses, including Student’s t-test, Mann-Whitney U test, Spearman correlation, and logistic regression, were used to compare groups and identify predictive factors.RESULTSThe individuals who tested positive and negative for anti-DFS70 included in the study were matched for age (median age=47y) and sex (F:M=7:1). CVI was significantly lower in the anti-DFS70-positive group compared to the negative group. A higher anti-DFS70 antibody titer was significantly associated with decreased subfoveal and nasal choroidal thickness (P=0.016 and P=0.014, respectively). In univariate regression analysis, CVI was the only significant predictor of anti-DFS70 positivity [odds ratio (OR)=0.02, P=0.025]. Multivariate analysis revealed a positive correlation between macular thinning outside the subfoveal area and anti-DFS70 status (P<0.05).CONCLUSIONOur study demonstrates a novel association between anti-DFS70 antibody positivity and reduced choroidal vascularity in healthy individuals. These findings suggest that anti-DFS70 antibodies may be associated with subtle choroidal vascular changes detectable by OCT, even in asymptomatic individuals. Further longitudinal research is warranted to clarify the underlying mechanisms and long-term clinical significance of these ocular changes.}
}