@article{Dong2026, 
author = {Xin Dong and Vijaya Raghavan and Shuo Wang},
title = {Cold Plasma-Induced Structural Reconfiguration and Allergenicity Modulation in Atlantic Cod: Linking Conformational Shifts to Digestibility and Immunoreactivity},
year = {2026},
journal = {Food Science and Human Wellness},
keywords = {Protein Structure, Allergenicity, Cold Plasma, Atlantic Cod, Functional Seafood},
url = {https://www.sciopen.com/article/10.26599/FSHW.2026.9250970},
doi = {10.26599/FSHW.2026.9250970},
abstract = {This study explores how atmospheric cold plasma (CP) modulates the nutritional and allergenic properties of Atlantic cod through structural protein alterations. CP at 10 min reduced parvalbumin content by 9.14%, likely via α-helix loss and β-sheet increase (confirmed by FTIR amide I shifts and CD analysis), which may hinder IgE epitope recognition. Antioxidant indices TAC, TFC, and TPC peaked at CP10 (21.56%, 68.48%) and CP30 (14.00%), respectively. Protein content increased by 10.76% (pre-digestion) and 30.20% (post-digestion) at CP20, while peptide release rose by 61.18% and 26.27% at CP30. Despite microstructural and conformational changes, digestibility remained stable. These findings highlight CP as a non-thermal strategy that enhances bioactive and hypoallergenic properties of cod, with potential for broader application to other high-allergen aquatic proteins.}
}