@article{Liu2026, 
author = {Meihan Liu and Bowen Li and Wei Zhou and Yicheng Lu and Yating Liu and Shiliang Chen and Yiwen Pan and Zehu Wang and Anxin Chen and Yijun Wang and Jiacheng Sun and Yuan Xu and Xin Wang and Jiawei Huo and Yang Liu and Wenhui Wang and Jinmeng Jia and Jie Li and Chunru Wang and Chunli Bai},
title = {Multitarget aminated fullerene hydrogels ameliorate psoriasis by scavenging ROS, inhibiting keratinocyte hyperproliferation, and reshaping the inflammatory microenvironment},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {6},
pages = {94908575},
keywords = {fullerene, psoriasis, reactive oxygen species (ROS), inflammation, keratinocyte hyperproliferation, multitarget mechanism, relapse},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908575},
doi = {10.26599/NR.2026.94908575},
abstract = {Psoriasis is a chronic inflammatory skin disease driven by oxidative stress, keratinocyte hyperproliferation, and immune dysregulation. Conventional single-target therapies frequently result in incomplete remission and disease relapse. Here, we designed amino-functionalized fullerene hydrogels (TAPC@CB/TPPC@CB) that coordinately restore oxidative and inflammatory homeostasis via a multitarget mechanism. These hydrogels normalize keratinocyte proliferation by upregulating the cell-cycle inhibitor Cdkn1b, inducing G0/G1 arrest, and eliminating excessive reactive oxygen species (ROS). They also promote macrophage polarization toward the anti-inflammatory M2 phenotype and downregulate stress-related and proinflammatory proteins, thereby inhibiting the NF-κB/IL-23/Th17 axis and restoring the inflammatory microenvironment. In vivo, topical TAPC@CB significantly reduced macrophage and T-cell infiltration, alleviated inflammation, and lowered recurrence risk. This study establishes amino-fullerene-based hydrogels as a single-agent, multipathway nanotherapeutic strategy for effective psoriasis treatment and relapse prevention.}
}