@article{Feng2026, 
author = {Jian Feng and Huixin Lv and Sicong Ren and Yuemeng Zhu and Yuzhu Han and Mucong Li and Jingxia Chen and Jiaxin Luo and Dixin He and Yidi Zhang and Yanmin Zhou},
title = {An NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {6},
pages = {94908573},
keywords = {chronic wound healing, near-infrared (NIR)-responsive nanoplatform, photothermal synergy, AMPK signaling pathway, mitochondrial homeostasis, cellular senescence},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908573},
doi = {10.26599/NR.2026.94908573},
abstract = {Chronic wound healing remains a significant clinical challenge due to persistent inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. A near-infrared (NIR)-responsive polydopamine-resveratrol (PDA@RES) core-shell nanoplatform was developed to address these interconnected pathological mechanisms through synergistic photothermal therapy and drug delivery. The nanoplatform exhibited excellent photothermal conversion capability and demonstrated superior antioxidant and anti-inflammatory effects, effectively scavenging intracellular reactive oxygen species (ROS), restoring mitochondrial membrane potential, and repolarizing macrophages toward a pro-healing phenotype. Mechanistically, the platform activated the AMPK/PGC-1α signaling axis, initiating programmed mitochondrial homeostasis remodeling through enhanced mitophagy and biogenesis, thereby blocking senescence-inducing signals and reversing cellular senescence. The immune microenvironment remodeling subsequently promoted vascular endothelial cell migration and angiogenesis. In diabetic rat models, the NIR-responsive nanoplatform significantly accelerated wound healing by promoting collagen deposition, balancing the immune microenvironment, and facilitating functional vascular regeneration. Notably, the treatment induced nascent hair follicle structures, achieving high-quality regenerative healing rather than scar formation. This study provides an efficient, multi-target synergistic therapeutic strategy for chronic wound healing.}
}