@article{Lang2026, 
author = {Jialu Lang and Chunlei Shan and Yuanzhi Ju and Qi Zhu and Jiawen Zhu and Xiaochuan Wu and Jiahao Hu and Yuanyan Huang and Di Chen and Gang Han and Yongzhong Du and Zhenwei Yu},
title = {Multifunctional nanoparticle-reinforced tissue-derived hydrogel for accelerated healing of drug-resistant Pseudomonas aeruginosa infected wounds},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {6},
pages = {94908546},
keywords = {wound healing, photothermal therapy, antibiotic resistance, extracellular matrix hydrogel, silver-decorated polydopamine},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908546},
doi = {10.26599/NR.2026.94908546},
abstract = {Chronic wounds complicated by multidrug-resistant bacterial infections pose a serious therapeutic challenge. Here, we develop a multifunctional hydrogel (PmB/Ag-PDA@ECM) by integrating silver nanoparticle-modified polydopamine (Ag-PDA) and polymyxin B (PmB) into a thermosensitive, pro-regenerative extracellular matrix (ECM) hydrogel. The hydrogel exhibits favorable physicochemical properties, including a porous microstructure (49.24% porosity), rapid swelling (~ 1068%), and strong tissue adhesion (6.24 kPa). Upon near-infrared (NIR) irradiation, it achieves mild photothermal heating (~ 50 °C), triggering synergistic antibacterial effects that completely eradicate polymyxin B-resistant Pseudomonas aeruginosa (PRPA). In vitro, the hydrogel promotes keratinocyte and endothelial cell proliferation and migration, while maintaining excellent cytocompatibility and hemocompatibility. In a PRPA-infected full-thickness wound model, the hydrogel rapidly sterilizes the wound bed and accelerates wound closure. Moreover, it effectively suppresses inflammation (reduced tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6)), promotes M2 macrophage polarization, and facilitates tissue remodeling, including neovascularization and regeneration of skin appendages. This work presents a clinically translatable hydrogel platform that simultaneously addresses antimicrobial resistance and supports high-quality tissue regeneration, offering a promising strategy for the treatment of complex infected wounds.}
}