@article{LI2026, 
author = {Wenjing LI and Yanjie BAI and Yan WANG and An LIU and Hangyao ZHANG and Yanjie LI},
title = {Research Progress of Adenosine Monophosphate-activated Protein Kinase in Post-stroke Cognitive Impairment},
year = {2026},
journal = {Medical Journal of Peking Union Medical College Hospital},
volume = {17},
number = {1},
pages = {230-237},
keywords = {adenosine monophosphate-activated protein kinase, stroke, cognitive impairment, signaling pathway, oxidative stress, neuroinflammatory regulation},
url = {https://www.sciopen.com/article/10.12290/xhyxzz.2024-0801},
doi = {10.12290/xhyxzz.2024-0801},
abstract = {Post-stroke cognitive impairment(PSCI) is one of the common complications in stroke patients, mainly manifested as impairments in memory, attention, and orientation. Adenosine monophosphate-activated protein kinase(AMPK), as a crucial intracellular energy sensor, has attracted extensive research attention in the field of PSCI in recent years. This paper provides a comprehensive review of the research progress on AMPK-related signaling pathways and their roles in PSCI, with a focus on exploring action mechanisms of AMPK in processes such as oxidative stress, neuroinflammation, autophagy, and apoptosis. Additionally, it summarizes the prospects and challenges of AMPK as a potential target for improving PSCI, aiming to offer new theoretical foundations for the clinical prevention and treatment of PSCI.}
}