@article{SONG2025, 
author = {Linqi SONG and Feng ZHENG},
title = {Preparation, characterization and in vitro release of diclofenac grafted with hyaluronic acid},
year = {2025},
journal = {Journal of China Pharmaceutical University},
volume = {56},
number = {1},
pages = {49-55},
keywords = {hyaluronic acid, diclofenac sodium, graft copolymer, characterization, in vitro release},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2024072601},
doi = {10.11665/j.issn.1000-5048.2024072601},
abstract = {In reference to the original drug diclofenac etalhyaluronate sodium (DF-HA), a graft copolymer was synthesized by covalent bonding. The structure of DF-HA was characterized by 1H NMR, UV-Vis spectrophotometry and FT-IR. The results showed that DF-HA was successfully synthesized, and the grafting rate was determined to be approximately 17% by 1H NMR and UV-Vis spectrophotometry. The in vitro release of DF-HA graft copolymer was studied by HPLC, and its release of diclofenac (DF) in phosphate buffered saline (PBS, pH 7.4) was investigated. The drug release rate of free DF was 83.6% after 6 h, and that of DF-HA was 4.8% within 1 d and 17.7% within 21 d, which were basically consistent with the release behavior of the reference listed drug. DF-HA could significantly achieve the sustained release of DF, and high molecular weight hyaluronic acid itself had the effect of treating osteoarthritis. With both advantages, DF-HA could have good application value.}
}