@article{TAN2025, 
author = {Yueyue TAN and Abdullaa RAHIMA and Deng ZANG and Shuping LI and Abulimiti XIAYIDAN and Xuelei XIN and Fei HE},
title = {Anti-vitiligo mechanism of blood-absorbed components of Carum carvi L. based on network pharmacology},
year = {2025},
journal = {Journal of China Pharmaceutical University},
volume = {56},
number = {5},
pages = {613-623},
keywords = {Carum carvi L., UPLC-Q-Exactive Orbitrap-HRMS, network pharmacology, melanogenic activity, anti-vitiligo, acacetin},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2025031402},
doi = {10.11665/j.issn.1000-5048.2025031402},
abstract = {To investigate the pharmacological substances basis and anti-vitiligo mechanism of Carum carvi L. (caraway) fruits,  chemical and blood-absorbed components were identified using mass spectrometry combined with literature study and database analysis. A “blood-absorbed components–target genes–pathways” network was constructed through network pharmacology. The pharmacological effects of Carum carvi L. extract and its key blood-absorbed component, acacetin, were validated in vitro. 72 chemical components were identified in the extract, with 11 prototype blood-absorbed components and 26 metabolites being detected in the plasma of SD rats. 14 key active components and 24 key targets were predicted. In vitro experiments demonstrated that acacetin at 10 μmol/L exhibited melanogenesis-promoting and tyrosinase-activating effects compared with the positive control, significantly upregulating the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase (tyrosinase, TYR). This study comprehensively analyzes the chemical and blood-absorbed components of Carum carvi L. and elucidates its pharmacological substances basis, which provides a theoretical foundation for the anti-vitiligo effects of acacetin.}
}