@article{WANG2025, 
author = {Yixuan WANG and Xin CHEN and Lian HE and Congcong ZHANG and Peiya SHEN and Yuan GAO and Jianjun ZHANG},
title = {Research progress of vacuum compression molding technology in pharmaceutical fields},
year = {2025},
journal = {Journal of China Pharmaceutical University},
volume = {56},
number = {5},
pages = {654-660},
keywords = {vacuum compression molding, amorphous solid dispersions, drug delivery system, hot melt extrusion, characterization analysis},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2024070303},
doi = {10.11665/j.issn.1000-5048.2024070303},
abstract = {Vacuum compression molding (VCM) is a novel technology supporting the research and development of pharmaceutical solid dispersions. It is widely applied due to its precision and convenience in sample preparation. This technology integrates the principles of heating, melting, cooling, and vacuum compression to transform solid powders into shaped solids directly. By selecting different molds, temperatures, and pressures, researchers can prepare samples with diverse characteristics. This paper presents an overview of the equipment composition and working principles of VCM technology, demonstrating its distinct advantages in the formulation screening process of amorphous solid dispersions through comparative analysis with hot melt extrusion using case studies, and introduces its applications in the development of drug delivery systems and rheological characterization analysis, with a perspective on the future development of its functions.}
}