TY  - JOUR
AU  - HAN, Xu
AU  - ZHOU, Qing
PY  - 2024
TI  - Review of autoinflammatory diseases pathogenic genes
JO  - Journal of Northwest University (Natural Science Edition)
SN  - 1000-274X
SP  - 811
EP  - 821
VL  - 54
IS  - 5
AB  - Autoinflammatory diseases (AIDs) is a group of inflammatory disease caused by excessive activation of innate immune system, with ubiquitous inflammation and involvement of multiple systems and organs. Genetics plays an important role in the pathogenesis of AIDs. So far, there are more than 50 monogenic AIDs causal genes have been described since the discovery of the first autoinflammatory disease. With the progress of immunological and genomic research, the spectrum of AIDs pathogenic genes was expanded with better interpretation of AIDs. With the introduction to AIDs causal genes and clinical phenotypes, we provide a comprehensive review of the pathogenesis of AIDs to better understand this group of disorders.
UR  - https://doi.org/10.16152/j.cnki.xdxbzr.2024-05-004
DO  - 10.16152/j.cnki.xdxbzr.2024-05-004