@article{Song2026, 
author = {Xin Song and Hui Li and Peng Meng and Guangqiang Wang and Fan Xie and Zhiqiang Xiong and Yijin Yang and Hui Zhang and Tingting Shen and Yongjun Xia and Lianzhong Ai},
title = {A fungal insoluble fiber from Antrodia camphorata modulates Ruminococcaceae and Helicobacter to restore lipid homeostasis via glycerophospholipid metabolism in HFD mice},
year = {2026},
journal = {Food Science and Human Wellness},
volume = {15},
number = {2},
pages = {9250938},
keywords = {High-fat diet, Insoluble dietary fiber, Ruminococcaceae, Lipid metabolic disorders, Antrodia camphorata},
url = {https://www.sciopen.com/article/10.26599/FSHW.2026.9250938},
doi = {10.26599/FSHW.2026.9250938},
abstract = {High-fat diets (HFD) disrupt lipid homeostasis, posing major public health risks. This study investigated the effect of ACA-DK, an insoluble dietary fiber derived from Antrodia camphorata, on HFD-induced dyslipidemia. We demonstrate that ACA-DK effectively alleviates HFD-induced dyslipidemia in mice, counteracting metabolic disorders, aberrant blood lipids, and weight gain. Mechanistically, ACA-DK modulates triglycerides, phosphatidylcholine, and phosphatidylethanolamine via glycerophospholipid/choline/linoleic acid metabolism pathways, while rectifying gut dysbiosis through selective reduction of pro-inflammatory genera (Oscillibacter, Ruminiclostridium, Negativibacillus, Ruminococcaceae and Helicobacter). Integrated analysis identifies Ruminococcaceae and Helicobacter as key mediators of ACA-DK’s lipid-regulatory effects, establishing microbiota-directed therapy as a strategy against dyslipidemia. We thus propose ACA-DK as a microbiota-directed dual-target therapy, simultaneously reprogramming host lipid metabolism and gut ecology to combat diet-induced metabolic diseases. These findings suggest that ACA-DK is a promising prebiotic dietary fiber for ameliorating HFD-induced lipid metabolic disorders, with potential for future development into functional foods or supplements.}
}