@article{Ma2025, 
author = {Mengge Ma and Lixiang Zheng and Xiaoyue Yao and Aijin Ma and Zhou Chen and Siting Li and Yingmin Jia},
title = {Mushroom polysaccharides regulate diet-induced obesity by targeting lipid metabolism, gut microbiota and mitochondria},
year = {2025},
journal = {Food Science and Human Wellness},
keywords = {Mushroom polysaccharides, Obesity, Lipid metabolism, Cholesterol metabolism, Gut microbiota, Mitochondrial dysfunction},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250855},
doi = {10.26599/FSHW.2025.9250855},
abstract = {Obesity, driven by unhealthy dietary patterns, has become a global health threat. Mushroom polysaccharides (MPs) exhibits promising protective effects against obesity. This review elucidate the potential anti-obesity mechanisms of MPs, focusing on their ability to modulate lipid metabolism, cholesterol homeostasis, gut microbiota, mitochondrial function, and oxidative stress. Specifically, MPs can protect against diet-induced obesity by improving lipid and cholesterol metabolism. Additionally, MPs improve obesity by modulating gut microbiota composition, which plays a pivotal role in lipid and energy metabolism. Moreover, diet-induced mitochondrial dysfunction, endoplasmic reticulum stress, and oxidative stress disrupt metabolic homeostasis through direct lipid dysregulation and inflammation-mediated pathways. MPs mitigate these effects by enhancing mitochondrial function, alleviating ER stress, and reducing oxidative stress, thereby restoring metabolic balance. This review presents a comprehensive discussion on MPs research as functional compounds utilized in food and medicine and could be beneficial for obesity and related metabolic disorders.}
}