@article{Tan2026, 
author = {Xiangyun Tan and Xueting Luo and Junjie Hu and Jiawei Liu and Xinyu Huang and Liang Chen and Ming Yuan and Cong Zhang and Yi Liu and Ziqiang Xu and Zhenpeng Qiu},
title = {Gallic acid/copper ion-based metal-phenolic networks as photothermal-enhanced nanocatalysts for cancer therapy},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {1},
pages = {94908285},
keywords = {tumor catalytic therapy, redox homeostasis, photothermal therapy, immunogenic cell death},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94908285},
doi = {10.26599/NR.2025.94908285},
abstract = {Tumor microenvironment-responsive nanocatalysts enhance reactive oxygen species (ROS) accumulation by compromising tumor antioxidant defenses, offering a promising cancer treatment strategy. Leveraging the catalytic potential of metal-phenolic networks (MPNs), this study constructed GA-Cu MPNs as multifunctional carriers. Since endogenous catalase (CAT) limits hydrogen peroxide (H2O2) accumulation, the CAT inhibitor 3-amino-1,2,4-triazole was encapsulated within the MPNs to form GA-Cu-AT, which was further modified with hyaluronic acid to produce GA-Cu-AT@HA. GA-Cu-AT@HA converts superoxide anions to H2O2, which is further transformed into toxic hydroxyl radicals through peroxidase-like activity, while inhibits endogenous CAT to amplify oxidative stress. Under 808 nm near-infrared light, it exhibits photothermal activity, enabling synergistic photothermal-catalytic effects. In vitro, it induces ROS accumulation, mitochondrial damage, apoptosis, and immunogenic cell death (ICD). In in situ hepatocellular carcinoma, GA-Cu-AT@HA effectively suppresses tumor growth, induces apoptosis, and enhances damage-associated molecular patterns release via targeted accumulation. In 4T1 breast cancer xenografts, photothermal therapy enhances the infiltration of CD8+ T cells into tumors, promotes dendritic cell maturation, and elicits systemic CD8+ T cell responses, and reduces regulatory T cells. This tripartite strategy, encompassing oxidative cytotoxicity, ICD activation, and immune microenvironment remodeling, offers a novel approach for tumor redox regulation therapy.}
}