@article{Guo2026, 
author = {Fan Guo and Rong-Shuang Huang and Rui-Han Li and Yu-Ying Feng and Lin Lin and Dong-Chuan Luo and Liang Ma and Ping Fu},
title = {Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice},
year = {2026},
journal = {Food & Medicine Homology},
volume = {3},
number = {3},
pages = {9420128},
keywords = {alcohol-associated liver disease, Sichuan dark tea, medicine-food-homology, liver steatosis, gut microbiota},
url = {https://www.sciopen.com/article/10.26599/FMH.2026.9420128},
doi = {10.26599/FMH.2026.9420128},
abstract = {Alcohol-associated liver disease (ALD) is a global health concern. Sichuan dark tea, a popular Chinese beverage, has been reported to have good health effects. In the study, Sichuan dark tea with a medicine-food-homology formula (TEA&MFH) has been created and evaluated for potential anti-ALD benefits. Our results exhibited that TEA&MFH treatment significantly decreased the mortality rate, hyperlipidemia, and hepatic steatosis in alcohol-induced mice. TEA&MFH treatment decreased serum ethanol levels and enhanced the expression of alcohol-metabolizing enzymes. Furthermore, TEA&MFH ameliorated alcohol-induced hepatic inflammation and fibrosis, maintained intestinal barrier integrity, and altered the composition of gut microbiota, particularly restoring the population of Akkermansia. Gene and metabolite integrated analysis revealed that TEA&MFH influenced these key pathways related to lipid metabolism and inflammatory response. These findings provide evidence that TEA&MFH synergistically improves alcohol-associated gut microbiota disturbance, liver steatosis, and death in mice. As a dietary formula, the TEA&MFH holds significant potential against alcoholic liver disease.}
}