@article{Zhan2025, 
author = {Minmin Zhan and Chenxi Zhao and Bin Chen and Xiaoxuan Wang and Peiyi Shen and Yanhui Han and Mingyue Song and Yong Cao and Hang Xiao},
title = {Orange Juice-Derived Nanovesicles Modulated High-Fat Diet-Induced Disorders of Bile Acids Metabolism},
year = {2025},
journal = {Food Science and Human Wellness},
keywords = {gut microbiota, high-fat diet, bile acids metabolism, orange juice-derived nanovesicles},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250780},
doi = {10.26599/FSHW.2025.9250780},
abstract = {Orange juice-derived nanovesicles (ONVs) have significant biological activity and may be utilized to prevent high-fat diet-associated gut dysbiosis. In this study, ONVs were isolated and characterized. They were then orally administered at three different doses in a high-fat diet-induced bile acids metabolic disorder mouse model to determine their effects on gut microbiota-bile acids metabolism. Our results showed that oral intake of ONVs reshaped the gut microbiota and its associated bile acids metabolism in high-fat diet mice by increasing microbial diversity, beneficial bacteria abundance, secondary bile acid concentration, and decreasing taurine-conjugated bile acids content. These findings support a new diet-based strategy utilizing ONVs to prevent metabolic diseases targeting bile acid metabolism.}
}