@article{LIN2025, 
author = {Yang LIN and Simiao SUN and Wenjuan XIN and Yanqing MAO and Rao CHEN and Ping SHAO},
title = {Preparation of Monascus Yellow Pigment Nanoparticles and Its Ameliorative Effect on Lipid Deposition in HepG2 Cells},
year = {2025},
journal = {Food Science},
volume = {46},
number = {20},
pages = {170-179},
keywords = {nanoparticles, lipid deposition, Monascus yellow pigment, galactosylated chitosan},
url = {https://www.sciopen.com/article/10.7506/spkx1002-6630-20250324-189},
doi = {10.7506/spkx1002-6630-20250324-189},
abstract = {To address the poor water solubility and low targeting ability of Monascus yellow pigment (MYP) from Monascus rice and thereby enhance its bioavailability, this study prepared MYP-zein-galactosylated chitosan nanoparticles (MYP-GC-NP) and evaluated its efficacy in ameliorating oleic acid/palmitic acid (OA/PA)-induced lipid accumulation in HepG2 cells. The results showed that MYP-GC-NP exhibited a spherical shape and uniform size distribution with an average particle size of (167.00 ± 0.60) nm, a polydispersity index (PDI) of 0.25 ± 0.01, and a ζ-potential of 70.88 mV. Additionally, compared with nanoparticles without modification by GC, MYP-GC-NP were more readily taken up by hepatocytes and significantly reduced intracellular lipid accumulation. This study provides a novel strategy to improve the bioavailability of MYP and offers a theoretical basis for the application of MYP-loaded nanoparticles in alleviating lipid accumulation.}
}