@article{Wang2025, 
author = {Rouye Wang and Wenbin Dai and Haojie Chen and Fang Liu and Weifeng Liu and Jian Ji and Qiao Jin},
title = {Zn2+-based nanoparticles eliminate intratumoral bacteria to synergistically enhance gemcitabine efficacy in pancreatic cancer therapy},
year = {2025},
journal = {Nano Research},
volume = {18},
number = {12},
pages = {94908194},
keywords = {metal-phenolic network, coordination self-assembly, Zn2+-containing nanoparticles, intratumoral bacteria, pancreatic cancer therapy},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94908194},
doi = {10.26599/NR.2025.94908194},
abstract = {Gemcitabine (Gem) is the gold-standard chemotherapeutic drug for pancreatic cancer therapy in clinic. However, intratumoral bacteria can metabolize Gem into an inactive form, leading to Gem resistance. To address this challenge, Zn2+-containing nanoparticles (ZGP NPs) are used to eliminate intracellular bacteria to enhance the therapeutic efficacy of Gem in pancreatic therapy. ZGP NPs are prepared via a facile one-pot method using Zn2+, epigallocatechin gallate (EGCG), and polyethylene glycol (PEG), which prevents metal ion chelation by proteins and ensures antibacterial activity. Leveraging the pH-responsive disassembly of metal-phenolic networks, ZGP NPs can be degraded in acidic lysosomes after cellular uptake, releasing Zn2+ to eliminate intracellular bacteria and thereby protecting Gem from bacteria-mediated inactivation. Moreover, the elimination of intratumoral bacteria enhances immunotherapy. The delivery of Zn2+ via ZGP NPs presents a promising strategy to eliminate intratumoral bacteria to overcome Gem resistance in pancreatic cancer therapy.}
}