@article{Xie2026, 
author = {Jiahao Xie and Huanrong Lan and Haojing Ma and Dian Jiang and Hongxin Yao and Yue Su and Junjia He and Weitao Huang and Ting Li and Yeyu Shen and Yuanyuan Wang and Xiaoru Chang and Xiangming Ye and Xin Chen and Zhenye Lv and Xiaozhou Mou and Qiong Bian and Xiangmin Tong},
title = {Oral Epimedium nanovesicles promote hematopoietic stem cell regeneration via gut-microbiota-bone marrow axis to mitigate chemotherapy-induced myelosuppression},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {1},
pages = {94908148},
keywords = {hematopoietic stem cells, myelosuppression, lactic acid, plant-derived exosome-like nanovesicles, intestinal floral, Epimedium},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94908148},
doi = {10.26599/NR.2025.94908148},
abstract = {Myelosuppression is a common and severe side effect of cancer chemotherapy, with current treatments hindered by limitations such as depletion of hematopoietic reserves, poor patient compliance, delayed therapeutic onset, and high cost. To overcome these challenges, we developed Epimedium-derived nanovesicles (ENVs) from the traditional Chinese medicinal herb Epimedium, addressing the solubility and bioavailability issues associated with conventional extracts. ENVs encapsulate bioactive constituents, including icariin and hematopoiesis-promoting ceramides. In a cyclophosphamide (CTX)-induced myelosuppression mouse model, prophylactic and therapeutic oral administration of ENVs effectively alleviated hematopoietic suppression, significantly outperforming the Epimedium-based herbal extract “Joungal” (Shengbai Formula) despite equivalent icariin content. Notably, ENVs promoted hematopoietic stem cell (HSC) proliferation—an outcome rarely achieved with existing therapies. Mechanistically, ENVs modulated the gut microbiota, enriching lactobacillus species and enhancing lactate production. This microbiota-driven lactate signaling stimulated LepR+ mesenchymal stem cells (MSCs) in the bone marrow niche to secrete stromal cell-derived factor-1 (SDF-1) and stem cell factor (SCF), thereby supporting HSC expansion and restoring hematopoietic function. In vivo safety evaluations confirmed the excellent biocompatibility of ENVs. Our findings uncover a gut–lactate–bone marrow axis through which ENVs enhance hematopoiesis and promote HSC regeneration. This work introduces a cost-effective, scalable, and orally administrable biomaterial platform with strong translational potential for the prevention and treatment of chemotherapy-induced myelosuppression.}
}