@article{Zhang2025, 
author = {Yameng Zhang and Rui Zhang and Chenyu Gao and Sitong Zhang and Wenyou Situ and Shan Yin and Zhuoqun Wang and Yufang Su and Nasi Ai and Huaxi Yi and Lingjun Tong},
title = {Oral administration properties and physiological functions evaluation of extracellular vesicles derived from colostrum and mature milk},
year = {2025},
journal = {Food Science and Human Wellness},
keywords = {physiological functions, milk extracellular vesicles, gastrointestinal tolerability, small RNA-sequence},
url = {https://www.sciopen.com/article/10.26599/FSHW.2025.9250663},
doi = {10.26599/FSHW.2025.9250663},
abstract = {Milk extracellular vesicles (mEVs) derived from colostrum (C-mEVs) and mature milk (M-mEVs) have been proposed as oral drug delivery platforms and potential nanomedicines. However, their differences in oral administration properties and physiological functions have not yet been documented. Here, we comprehensively evaluated the biological properties and physiological functions of C-mEVs and M-mEVs, emphasizing their storage stability, gastrointestinal tolerability, and functional differences revealed through small RNA sequencing. Our findings showed that both C-mEVs and M-mEVs exhibit excellent stability at 4℃ and -80℃ over one month. Furthermore, C-mEVs, characterized by their smaller size, demonstrated greater tolerance to harsh digestive environments compared to M-mEVs. For physiological functions, both C-mEVs and M-mEVs suppressed inflammation, protected epithelial barrier integrity, and mitigated oxidative stress damage. Notably, M-mEVs displayed enhanced anti-inflammatory and antioxidative effects. Taken together, M-mEVs hold potential as nanotherapeutic agents for immunoinflammatory diseases, while C-mEVs may serve as a promising oral drug delivery platform.}
}