@article{WU2016, 
author = {Xiao-ping WU and Da-ming ZHANG and Wei-liang CHEN},
title = {Clinical observation of treating infantile head and neck hemangioma with oral propranolol},
year = {2016},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {24},
number = {3},
pages = {158-161},
keywords = {Propranolol, Hemangioma, Vascular anomalies, Head and neck, Infant},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2016.03.007},
doi = {10.12016/j.issn.2096-1456.2016.03.007},
abstract = {ObjectiveTo evaluate the treatment effect and drug safety of treating infantile head and neck hemangioma with oral propranolol.MethodsOral propranolol was applied to 68 infants(male 20 cases, female 48 cases, from 1 to 9-month-old, with an average age of 4. 2 month) with heamngiomas. The daily dose of propranolol was increased from 0. 5 mg / kg at the first day to 1. 0 mg / kg at the second day, and to 2 mg / kg at the third day. The daily dose was given equally every 8 hours. A therapy dose of 2 mg / kg / day was given until 1-year old, and the patients were visited every month. The changes of tumor size, texture, color and adverse effects were monitored. The short-term results were evaluated and adverse effects after medication were observed and managed accordingly by Achauer criterion.ResultsAlthough side effects were noted in 23 cases (33. 8%), most were mild adverse effects and propranolol therapy was continued after symptomatic treatment. 2 patients (2. 9%) were stopped therapy due to hypotension and abnormal liver function after drug administration. The results were evaluated using Achauer system, scale Ⅰ (poor) in 6 patients (8. 8%), scale Ⅱ (moderate) in 11 patients(16. 2%), scale Ⅲ (good) in 17 patients (25%) and scale Ⅳ (excellent) in 32 patients (47. 1%).ConclusionOral propranolol treatment of infantile hemangioma has elicited high efficacy and tolerance with few expected adverse effects. It might be used as the first-line treatment for infantile head and neck hemangioma.}
}