@article{Han2025, 
author = {Jiaping Han and Kai Fu and Zhiqiang Jiang and Hao Zhang and Hongshan San and Hui Chen and Xiaopeng Lu and Carsten Blawert and Mikhail.L. Zheludkevich},
title = {Smart gradient coating suitable for bone growth prepared on plasma-electrolytically oxidised Mg and its sequential degradation behaviour},
year = {2025},
journal = {Journal of Magnesium and Alloys},
volume = {13},
number = {1},
pages = {356-378},
keywords = {Biomedical magnesium alloys, Gradient coating, Sequential degradation, Barrier property, Bone formation, Biocompatibility},
url = {https://www.sciopen.com/article/10.1016/j.jma.2024.05.026},
doi = {10.1016/j.jma.2024.05.026},
abstract = {A gradient coating containing collagen and inorganic strontium/calcium phosphate (Sr/CaP) was fabricated on plasma-electrolytically oxidised magnesium via one-step cathodic electrodeposition. First, Sr-doped dicalcium phosphate dihydrate and hydroxyapatite (DCPD and HA) was deposited, followed by a collagen/CaP layer. The morphological evolution, sequential degradation behaviour, and in vitro bio-properties of the coatings were investigated. The incorporation of collagen remarkably refined the morphology of the CaP, and a more aggregated nano-spherical morphology was observed with increasing collagen concentration. Sr could partially replace Ca in the CaP crystals. Collagen combined with CaP formed a relatively stable skeletal frame, which provided sufficient barrier properties and more sites for the re-precipitation of bone tissue, as well as a more promising proliferation and differentiation ability of osteoblasts. A gradient coating that matches the requirements of bone growth at various periods is suggested for implantation.}
}