@article{XU2023, 
author = {Ruonan XU and Yiru WEI and Xintong YANG and Awuti GULINUER},
title = {Systematic review of clinical effects of enamel matrix derivative as adjunctive therapy for gingival recession},
year = {2023},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {31},
number = {4},
pages = {261-266},
keywords = {enamel matrix derivative, connective tissue graft, gingival recession, keratinized tissue width, probing depth, clinical attachment loss, randomized controlled trial, meta analysis, systematic review},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2023.04.006},
doi = {10.12016/j.issn.2096-1456.2023.04.006},
abstract = {ObjectiveTo evaluate the clinical effect of enamel matrix derivative(EMD) assisted with connective tissue graft(CTG) in the treatment of gingival recession.MethodsSearch The Cochrane Library, PubMed, EMbase, Web of Science, Wanfang Public Database, VIP database and CNKI to search for randomized controlled trials of EMD in the treatment of gingival recession. The search period is from the establishment of the databases to October 3, 2022. The test group was treated with EMD+CTG, while the control group was treated with CTG alone. Meta-analyses were performed using Review Manager 5.4.1 and Stat12.0.ResultsMeta analysis results showed that only 12 months after treatment, there was a statistically significant difference in the PD and CAL outcome indicators between the EMD assisted treatment group and the control group [MDPD=-0.10, 95% CI (-0.19, -0.01), P = 0.03], [MDCAL=-0.38, 95% CI (-0.71, -0.04), P = 0.03]. There was no significant difference between the test group and the control group in other indicators.ConclusionEMD assisted CTG in the treatment of gingival recession may be beneficial to the reduction of PD and CAL.}
}