@article{SHI2022, 
author = {Binmian SHI and Xudong XIE and Jun WANG},
title = {The role of Axin2+ cells in periodontal tissue development and regeneration},
year = {2022},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {30},
number = {6},
pages = {433-437},
keywords = {WNT signaling pathway, Axin2, periodontal tissues, development, regeneration, stem cell, homeostasis, celllineage tracing},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2022.06.008},
doi = {10.12016/j.issn.2096-1456.2022.06.008},
abstract = {As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive (Axin2+) cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2+ cells in periodontal tissue development and the role and regulatory mechanism of Axin2+ cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2+ cells were the main cell source of periodontium development, and Axin2+ cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2+ cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2+ cells remain to be elucidated.}
}