@article{LIN2022, 
author = {Yao LIN and Jing HUANG and Xiaojuan XUE and Huan ZHANG and Bin FENG},
title = {Adverse drug reactions induced by hydroxychloroquine in the treatment of oral lichen planus: a report of 13 cases},
year = {2022},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {30},
number = {5},
pages = {350-354},
keywords = {hydroxychloroquine, oral mucosal disease, adverse-drug reaction, optic neurotoxicity, vision screening, cardiotoxicity, medication safety, package inserts of drug},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2022.05.007},
doi = {10.12016/j.issn.2096-1456.2022.05.007},
abstract = {ObjectiveTo analyze the adverse drug reaction（ADR）reports of hydroxychloroquine for clinical medication safety.MethodsThe ADR reports of hydroxychloroquine between May 2019 and May 2021 were analyzed. Age, reasons for drug use, time of ADR, combined drug use, and ADR outcomes were statistically analyzed.ResultsNo severe ADR was reported. Patients over 60 years old accounted for 53.85% of the total cases, and the time of ADR appearance was significantly earlier among those under 60 years old. A total of 61.54% of ADRs were involved in multiple organs, and optic neurotoxicity was reported in 46.15% of cases.ConclusionIn the treatment of oral lichen planus with hydroxychloroquine, adverse drug reactions should be monitored, and increased attention should be given to patients over 60 years old to ensure the safety of this medication.}
}