@article{ZHOU2021, 
author = {Anqi ZHOU and Jiayi LIU and Yinan JIA and Lin XIANG},
title = {Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration},
year = {2021},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {29},
number = {5},
pages = {334-339},
keywords = {osseointegration, bone repair, Hippo-YAP signaling pathway, osteoimmunology, implants, osteogenesis, bone remodeling, macrophages},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2021.05.007},
doi = {10.12016/j.issn.2096-1456.2021.05.007},
abstract = {Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.}
}