TY  - JOUR
AU  - ZHOU, Anqi
AU  - LIU, Jiayi
AU  - JIA, Yinan
AU  - XIANG, Lin
PY  - 2021
TI  - Research progress on the Hippo-YAP signaling pathway mediated osteoimmunology in modulating implant osseointegration
JO  - Journal of Prevention and Treatment for Stomatological Diseases
SN  - 2096-1456
SP  - 334
EP  - 339
VL  - 29
IS  - 5
AB  - Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.
UR  - https://doi.org/10.12016/j.issn.2096-1456.2021.05.007
DO  - 10.12016/j.issn.2096-1456.2021.05.007