@article{WANG2021, 
author = {Ziying WANG and Xiaotao CHEN},
title = {Research progress on the role of T helper cells 17 and interleukin 17 in oral mucosal diseases},
year = {2021},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {29},
number = {3},
pages = {194-197},
keywords = {T helper cells 17, interleukin 17, oral mucosal disease, oral lichen planus, oral ulcer, recurrent aphthous ulcer, Behcet′s disease, proinflammatory effect},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2021.03.009},
doi = {10.12016/j.issn.2096-1456.2021.03.009},
abstract = {T helper 17 (Th17) cells are a new type of CD4+ T helper cell. They participate in the immune and inflammatory response by secreting specific interleukin-17 (IL-17). In oral mucosal diseases, oral lichen planus (OLP), recurrent aphthous ulcer (RAU) and Behcet′s disease (BD) are associated with Th17 cells and IL-17. There were 17 kinds of proteins in the saliva of patients with OLP that could upregulate the expression of Th17 cells and induce the secretion of IL-17. IL-17 can stimulate epithelial cells, endothelial cells and fibroblasts to produce a variety of cytokines, such as IL-6, IL-8, granulocyte macrophage colony-stimulating factor and cell adhesion molecule-1, leading to the production and aggravation of inflammation. Th17/Tc17 cell-targeted therapy can significantly improve the clinical symptoms of OLP patients′ mucosa and skin. IL-17 can stimulate oral keratinocytes through the IL-17RA or IL-17RE receptor and produce proinflammatory effects in RAU. Th17 cells in the peripheral blood of BD patients are significantly increased, while Treg cells are significantly decreased.}
}