@article{LUO2021, 
author = {Yongxi LUO and Xueying HUANG and Ruoting XIAN and Wanxin YU and Lixin LIANG and Zhaojia LIANG and Ziyun CHEN and Dan HOU and Ting YU},
title = {Micro-CT analysis of hyperuricemia on alveolar bone destruction caused by short-term periodontal infection in mice},
year = {2021},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {29},
number = {2},
pages = {88-93},
keywords = {hyperuricemia, uric acid, periodontitis, murine model, alveolar bone resorption, micro-CT, bone volume fraction, bone mineral density},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2021.02.003},
doi = {10.12016/j.issn.2096-1456.2021.02.003},
abstract = {ObjectiveEstablish a murine model for hyperuricemia (HU) and periodontitis to explore whether there is correlation between them and provide a basis for periodontal treatment.MethodsFourteen male KM mice were divided into 2 groups; the HU group (n＝7) was fed food supplemented with potassium oxonate and uric acid, the NC group (n＝7) was fed standard food, and the induction period was 35 days. On the 25th day, the molars on one side were ligated to induce periodontitis (P side), while the opposite was true for the control (C side). Baseline and terminal serum uric acid (UA) levels were detected, and alveolar bone resorption was analyzed by micro-CT.ResultsThe serum UA level of HU mice was (112.94 ± 26.82 )mol/L, that of the NC group was (72.21 ± 19.95) μmol/L, and the difference in UA level was statistically significant (P < 0.05). The P side bone volume fractions of the HU and NC groups were( 29.01 ± 11.09)% and (29.56 ± 15.27)%, respectively, which were not significantly different (t＝-0.072, P＝0.944). The P side bone mineral densities of the HU and NC groups were(0.53 ± 0.16) g/cm3 and (0.52 ± 0.14) g/cm3, respectively, which were not significantly different (t＝0.038, P＝0.970). Additionally, there was no correlation between HU or serum UA and alveolar bone resorption (P > 0.05).ConclusionThis research established a murine model for HU and periodontitis, but based on micro-CT analysis of alveolar bone, no relationship between HU or UA levels and periodontitis was found.}
}