@article{HUANG2019, 
author = {Lihuan HUANG and Yingtong JIANG and Kexiong OUYANG and Lihong WU and Xuechao YANG},
title = {Research progress on the role and mechanism of miR-155 in the development of oral squamous cell carcinoma},
year = {2019},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {27},
number = {12},
pages = {809-812},
keywords = {oral squamous cell carcinoma, oncogene, microRNA, miR-155, epstein-barr virus(EBV), human papillomavirus(HPV), target gene, biomarker},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2019.12.012},
doi = {10.12016/j.issn.2096-1456.2019.12.012},
abstract = {Oral squamous cell carcinoma (OSCC) is the most common oral cancer. Previous studies have found significantly high miR-155 expression in OSCC. However, the mechanism by which miR-155 plays a role in OSCC oncogenesis is not yet clear. This article reviews the function of the relationship between miR-155 and tumors and the potential role of miR-155 in the development of OSCC. A literature review showed that mir-155, as a small carcinogenic RNA, can inhibit CDC73, BCL6, P27Kip1 and other target genes that play a role in cancer inhibition; promote the proliferation, migration and invasion of OSCC cells; and inhibit apoptosis. miR-155 can also be combined with biological factors (Epstein-Barr virus, human papillomavirus) to promote the development of OSCC.}
}