@article{GUI2019, 
author = {Xinwei GUI and Xiaowu YAO and Shisheng CHEN and Zizheng LU and Minxiao LIN and Yu PENG},
title = {Expression of NF-κB in oral squamous cell carcinoma and paracancerous tissues and its significance},
year = {2019},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {27},
number = {6},
pages = {360-363},
keywords = {Oral neoplasms, Carcinoma, squamous cell, paracancerous tissues, NF-κB},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2019.06.004},
doi = {10.12016/j.issn.2096-1456.2019.06.004},
abstract = {ObjectiveTo investigate the expression and significance of NF-κB in oral squamous cell carcinoma and paracancerous tissues.MethodsCancerous and paracancerous tissues about 5 mm outside the tumor boundary were cut from 47 patients with OSCC. NF-κB expression in these tissues were detected by the immunohistochemical SP method and compared with that in 32 normal oral mucosa tissues.ResultsThe average optical density (OD value) of immu-nohistochemical-positive cells in cancer tissues and paracancerous tissues was higher than that in normal tissues, and the difference was statistically significant (P < 0.001). There was no significant difference in the OD values between cancer tissues and paracancerous tissues (P＝0.356). The rate of NF-κB positive expression in cancer tissue and paracancerous tissue was significantly higher than that in normal mucosa tissue, and the difference was statistically significant (P < 0.001). There was no significant difference in the rate of NF-κB positive expression between cancer tissues and paracancerous tissues (P＝0.117), but the rate of moderate-to-strong positive expression in cancer tissues was significantly higher than that in paracancerous tissues (P < 0.001).ConclusionNF-κB may be involved in the development of OSCC.}
}