@article{ZHU2019, 
author = {Yanxia ZHU and  Gegentana},
title = {Research progress of IL-33/ST2 signaling pathway in bone metabolism},
year = {2019},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {27},
number = {3},
pages = {202-204},
keywords = {IL-33, ST2, Osteoclast, Osteoblast, Bone metabolism, Interleukin-1 receptor accessory protein, Periodontitis, Periapical periodontitis},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2019.03.012},
doi = {10.12016/j.issn.2096-1456.2019.03.012},
abstract = {Interleukin-33(IL-33) is a new member of the interleukin-1 (IL-1) cytokine superfamily. It can activate mast cells, lymphocytes and macrophages to produce Th2 cytokines and plays a very important role in inflammation, infection, and autoimmune disease. The classical signal pathway of IL-33 includes the isotrimer of ST2 and interleukin-1 receptor accessory protein (IL-1 RAcP), which transduces signals into cells. The IL-33/ST2 signaling pathway affects bone metabolism by activating T and B lymphocytes. This article reviews the role of the IL-33/ST2 signaling pathway in bone metabolism. The results of a literature review showed that at present, scholars at home and abroad still dispute the role of IL-33 in bone metabolism. Some scholars believe that IL-33 can inhibit osteoclast formation, and IL-33 has been recently implicated in physiological bone remodeling. However, other scholars believe that IL-33 can promote osteoclast formation and differentiation, which leads to bone absorption. IL-33 and its signaling pathway are involved in bone metabolism of alveolar bone in periodontitis and periapical periodontitis. The specific mechanism remains unclear, and further studies are warranted.}
}