@article{TIAN2019, 
author = {Yuanye TIAN and Zhangui TANG},
title = {Research progress on the CD4+T cell balance in oral cancer and precancerous diseases},
year = {2019},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {27},
number = {2},
pages = {115-121},
keywords = {Th1, Th2, Th17, Regulatory T cell, Oral squamous cell carcinoma, Oral precancerous lesion},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2019.02.010},
doi = {10.12016/j.issn.2096-1456.2019.02.010},
abstract = {CD4+T cells play an important role in regulating adaptive immune responses to various inflammatory responses. Parental T cell populations can differentiate in response to different cytokines into at least four subpopulations: Th1, Th2, Th17, and Treg cells. These differentiated T cells participate in various immune responses and have different roles and functions in oral cancer and precancerous diseases. The Th1/Th2 balance, the Th17/Treg balance and the occurrence and development of oral cancer and precancerous diseases are related to immune imbalances. Reversing these T cell imbalances and strengthening the patient's autoimmune function may prevent or even reverse the progression of oral and precancerous diseases. This paper reviews the research advances on the CD4+T cell balance in oral cancer and precancerous lesions.}
}