@article{CHEN2018, 
author = {Yuxiong CHEN and Yuanjin HUANG},
title = {Study progress of the correlation between peri-implantitis，IL-1β，TNF-α and NF-κB signal transduction},
year = {2018},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {26},
number = {10},
pages = {673-676},
keywords = {Peri-implantitis, Interleukin-1β, Tumor necrosis factor-α, Receptor activator for nuclear factor-κB ligand, Osteoprotegerin, Nuclear transcription factor kappaB signaling pathways},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2018.10.012},
doi = {10.12016/j.issn.2096-1456.2018.10.012},
abstract = {Increasing numbers of edentulous patients and patients with dental defects are willing to accept implant restorations. However，the development of peri-implantitis is a major factor leading to implant failure. The worsening of peri-implantitis promotes the secretion of inflammatory cytokines such as IL-1β and TNF-α and the gene expression of RANKL，inhibits the gene expression of OPG，and increases osteoclast activity，which promotes bone absorption indirectly and leads to a negative balance in bone metabolism. To gain knowledge about the relationship between peri-implantitis and NF-κB signaling pathways，this article summarizes related reports about peri-implantitis and NF-κB signaling pathways，explores the regulatory mechanism by which peri-implantitis affects bone metabolism and NF-κB signaling，discusses the effect of immunological cytokines on NF-κB signaling pathways when inflammation arises，and provides a theoretical foundation for peri-implantitis research and prevention.}
}