@article{LI2017, 
author = {Jing LI and Jing LIANG and Ting XU and Fengqing TAN and Juan LIU and Xiongqun ZENG},
title = {Relationship between interleukin-6 -572 gene polymorphism and aggressive periodontitis in Chinese},
year = {2017},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {25},
number = {11},
pages = {718-722},
keywords = {Interleukin-6, Chronic periodontitis, Aggressive periodontitis, Single nucleotide polymorphism, Allele},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2017.11.008},
doi = {10.12016/j.issn.2096-1456.2017.11.008},
abstract = {ObjectiveTo investigate the association between interleukin-6 -572 gene polymorphism and aggressive periodontitis.MethodsA case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health controls was held, and the genotype and allele distributions of interleukin-6 -572 gene polymorphism were analyzed by PCR-RFLP.ResultsThere was statistically significant differences in the genotype distribution by the chi-square test in the two groups (χ2 = 13.710, P＝0.001). The distribution of allele frequencies in AgP group was statistically different (χ2＝13.213, P < 0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI: 1.634-5.465) when compared with the C allele.ConclusionIL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chinese Han population of Guangdong, and the IL-6 -572 G allele might be a risk factor of the genetic susceptibility to AgP.}
}