@article{WANG2017, 
author = {Lihong WANG and Wenbiao ZHANG and Lijun XI and Aiqin BAO and Shiguang HUANG},
title = {Effects of non-surgical periodontal treatment on level of vaspin and TNF-α in gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis},
year = {2017},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {25},
number = {6},
pages = {360-364},
keywords = {Visceral adipose tissue-derived serine protease inhibitor, Tumor necrosis factor-alpha, Gingival crevicular fluid, Periodontitis, Type 2 diabetes mellitus},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2017.06.004},
doi = {10.12016/j.issn.2096-1456.2017.06.004},
abstract = {ObjectiveTo investigate the changes of vaspin and TNF-α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non-surgical periodontal treatment.Methods60 subjects were divided into 4 groups: DM-CP group (patients with both T2DM and CP, n＝15); CP group (CP patients without T2DM, n＝15); DM group (T2DM patients without CP, n＝15), and CTRL group (systemically and periodontally healthy individuals, n＝15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non-surgical periodontal treatment. The levels of vaspin and TNF-α were measured by ELISA.ResultsThe levels of vaspin and TNF-α in CP group were significantly higher than those in CTRL group (P < 0.05), while the levels of vaspin and TNF-α in CP group were significantly decreased after treatment (P < 0.05). There was a statistically significant positive correlation between the total amount of vaspin and the total amount of TNF-α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05).ConclusionThe results shows that vaspin and TNF- α are greatly decreased in periodontitis after non-surgical periodontal treatment. It suggests that vaspin and TNF- α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.}
}