@article{ZHAO2016, 
author = {Shu-fan ZHAO and Ying-qiu CUI},
title = {Protective effect of baicalin on oxidative stress-induced apoptosis of gingival epithelial cells},
year = {2016},
journal = {Journal of Prevention and Treatment for Stomatological Diseases},
volume = {24},
number = {12},
pages = {701-705},
keywords = {Baicalin, Oxidative stress, Apoptosis, Gingival epithelial cells, Periodontitis},
url = {https://www.sciopen.com/article/10.12016/j.issn.2096-1456.2016.12.004},
doi = {10.12016/j.issn.2096-1456.2016.12.004},
abstract = {ObjectiveTo study the protective effect of baicalin on oxidative stress- induced gingival epithelial cell apoptosisand its mechanism.MethodsH2O2 was employed to form the oxidative stress - induced gingival epithelial cells apoptotic model, with the intervention of baicalin. The cell proliferation rate, cell apoptosis level, the protein expression of protein kinase B (Akt) and glycogen synthase kinase3β (GSK3β) were investigated respectively.ResultsBaicalin could effectively alleviate oxidative stress-induced inhibition of gingival epithelial cell proliferation and alleviate apoptosis; and it could promote the phosphorylation of Akt-GSK3β signaling pathway.ConclusionBaicalin has a significant protective effect on oxidative stress-induced apoptosis of gingival epithelial cells, which may be related to the regulation of Akt-GSK3β signal pathway.}
}