@article{Quan2025, 
author = {Wenjun Quan and Kizito Eneye Bello and Rafidah Hanim Shueb and Nazri Mustaffa},
title = {Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances},
year = {2025},
journal = {Genes & Diseases},
volume = {12},
number = {5},
pages = {101605},
keywords = {Biomarker, circRNA, Hepatitis B virus, Hepatocellular carcinoma, Therapy},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2025.101605},
doi = {10.1016/j.gendis.2025.101605},
abstract = {Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a liver disease with substantial global impact. Despite efforts towards adequate management, the survival of patients with HBV-induced HCC has been consistently low. circRNAs regulate various physiological activities of HBV-induced HCC. This review aims to elucidate the biogenesis of circRNAs and the pathophysiology of HBV-induced HCC and comprehensively analyze the applications of circRNAs in oncology and therapeutics. In addition, this review summarizes past research achievements on circRNAs in HBV-induced HCC. Finally, the limitations of existing methodologies and circRNA research in HBV-induced HCC have been discussed to provide a blueprint for future investigations.}
}