TY  - JOUR
AU  - Quan, Wenjun
AU  - Bello, Kizito Eneye
AU  - Shueb, Rafidah Hanim
AU  - Mustaffa, Nazri
PY  - 2025
TI  - Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances
JO  - Genes & Diseases
SN  - 2352-4820
SP  - 101605
VL  - 12
IS  - 5
AB  - Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a liver disease with substantial global impact. Despite efforts towards adequate management, the survival of patients with HBV-induced HCC has been consistently low. circRNAs regulate various physiological activities of HBV-induced HCC. This review aims to elucidate the biogenesis of circRNAs and the pathophysiology of HBV-induced HCC and comprehensively analyze the applications of circRNAs in oncology and therapeutics. In addition, this review summarizes past research achievements on circRNAs in HBV-induced HCC. Finally, the limitations of existing methodologies and circRNA research in HBV-induced HCC have been discussed to provide a blueprint for future investigations.
UR  - https://doi.org/10.1016/j.gendis.2025.101605
DO  - 10.1016/j.gendis.2025.101605