@article{Tao2025, 
author = {Nana Tao and Qingru Sun and Yuyuan Ying and Yitao Wang and Jianli Gao},
title = {Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration},
year = {2025},
journal = {Genes & Diseases},
volume = {12},
number = {5},
pages = {101518},
keywords = {Autoimmunity, Hair, Hair follicle regeneration, Immune homeostasis, T cell},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2025.101518},
doi = {10.1016/j.gendis.2025.101518},
abstract = {Mammalian hair follicles undergo periodic regeneration, with recent research high-lighting the immunological niche as a critical regulator of stem cell activity and hair follicle regeneration. Chemotactic signals from hair follicles attract macrophages and T cells, which, in turn, control the resting and differentiation of epithelial stem cells in both healthy and damaged conditions. T cells play a pivotal role in hair follicle regeneration, contributing to injury-induced hair neogenesis and physiologic hair cycling. However, disruption of this interaction can lead to clinically significant immune-mediated alopecia. Both scarring and non-scarring forms of alopecia arise from an imbalance in this dynamic system. In this review, we address the role of T cells in hair follicles, summarize related mechanisms, and highlight key genes involved in T cell differentiation and development. Our aim is to provide insights into the development of hair disorders linked to T cell immune homeostasis and hair follicle regeneration.}
}