@article{Qin2026, 
author = {Jiaqi Qin and Hongrui Tian and Weina Cai and Hui Chen and Zouguang Han and Yanfeng Bi and Baokuan Chen},
title = {Dual-site synergistic copper-polyoxoniobate: Ultralow-energy mechanochemical synthesis of bioactive 4H-pyrans},
year = {2026},
journal = {Nano Research},
volume = {19},
number = {2},
pages = {94908029},
keywords = {copper-polyoxoniobate, mechanochemistry, synergistic catalysis, multicomponent reactions, heterocycles synthesis},
url = {https://www.sciopen.com/article/10.26599/NR.2025.94908029},
doi = {10.26599/NR.2025.94908029},
abstract = {A copper-polyoxoniobate cluster (Cu-PONb) featuring Lewis acid/base dual sites was developed for the ultralow-energy mechanochemical synthesis of pharmacologically relevant 2-amino-3-cyano-4H-pyrans (ACPs). This solvent-minimized protocol enables an efficient, one-pot, three-component coupling of aldehydes, malononitrile, and diketones at room temperature with minimal energy input (e.g., 8 Hz oscillating frequency). The method exhibits exceptional substrate scope, scalability, and superior reactivity compared to conventional solution-phase approaches. Mechanistic studies reveal that the synergistic catalysis of Cu-PONb presents dual reaction pathways (Knoevenagel condensation followed by Michael addition/intramolecular cyclization), representing the first report of a mechanochemically driven polyoxometalate catalyst for ambient multicomponent reactions. This work presents a green and sustainable approach to accessing valuable bioactive heterocycles.}
}