@article{Yang2025, 
author = {Meng Yang and Qifeng Dang and Siyu Niu and Shiyun Wang and Yan Zhao and Jieyu Su and Feng Sang and Chengsheng Liu},
title = {Preparation and Characterization of Multifunctional Hydrogels Based on Modified Chitosan/Oxidized Glucomannan},
year = {2025},
journal = {Periodical of Ocean University of China},
volume = {55},
number = {6},
pages = {76-89},
keywords = {chitosan, glucomannan, hydrogel, antioxidation, self-recovery},
url = {https://www.sciopen.com/article/10.16441/j.cnki.hdxb.20230345},
doi = {10.16441/j.cnki.hdxb.20230345},
abstract = {To develop multifunctional hydrogels possessing excellent biocompatibility, antibacterial activity, and antioxidant property, as well as suitable adhesion and degradability, we innovatively modified chitosan (CS) by using hydrotropic acid (HA) for obtaining HA-modified CS (CSHA) in this work. FTIR and UV-Vis results showed that CSHA with a grafting degree of 26.64% was successfully synthesized via the amide reaction. Compared to that of CS, the crystallinity of CSHA decreased and its solubility was improved. Simultaneously, oxidized glucomannan (OGM) with an oxidation degree of 24.07% was acquired through the periodate oxidation method. Based on the above outcomes, four kinds of CSHA/OGM hydrogels (CH-OG-HGs) were successfully constructed via the Schiff base reaction, and their physicochemical and biological properties were studied. Experimental results revealed that CH-OG-HGs had a short period of gelation time (< 70 s), a maximum equilibrium swelling rate of 17.54%, a maximum adhesion strength of 1400 kPa, and a high degradation rate (> 99.39%) within 30 days. Rheological test results showed that CH-OG-HGs had shear thinning characteristics, self-healing property, and appropriate mechanical strength. SEM results indicated that CH-OG-HGs possessed interconnected three-dimensional network structures. CH-OG-HGs had much low cytotoxicity to L929 and HSF cells, and their hemolysis rates were less than 5%, which is in accord with the standards of biomedical materials. Furthermore, CH-OG-HGs exhibited a remarkable inhibition rate (up to 95.94%) against both E. coli and S. aureus, and different radical scavenging ratios of around 90% for ABTS+· and 40% for ·OH. In summary, CH-OG-HGs not only possessed suitable mechanical strength, adhesive strength, swelling property, and low toxicity, but also had excellent antibacterial, antioxidant, injectable, degradable, and self-recovery properties, which collectively highlights their enormous potential for application in various biomedical fields such as wound dressings, drug release carriers, and tissue engineering materials.}
}